Synthesis of optically active N??protected α??aminoketones and α??amino alcohols

ZH Zhou, YL Tang, KY Li, B Liu…

Index: Zhou, Zheng Hong; Tang, Yi Long; Li, Kang Ying; Liu, Bing; Tang, Chu Chi Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 603 - 606

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Citation Number: 10

Abstract

Abstract A series of optically active N-protected α-aminoketones were synthesized via the Grignard reaction of the Weinreb amides of the N-tert-butoxycarbonyl amino acids. Reduction of the α-aminoketones by sodium borohydride resulted in the corresponding 1, 2- amino alcohols.© 2003 Wiley Periodicals, Inc. Heteroatom Chem 14: 603–606, 2003; Published online in Wiley InterScience (www. interscience. wiley. com). DOI 10.1002/hc. ...