Organic Letters 2000-07-27

Expanded scope in ethylene-alkyne cross-metathesis: coordinating heteroatom functionality at the propargylic position.

J A Smulik, S T Diver

Index: Org. Lett. 2 , 2271, (2000)

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Abstract

The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene-alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.