Journal of the American Chemical Society 2010-05-05

N-heterocyclic carbene-catalyzed cascade reaction involving the hydroacylation of unactivated alkynes.

Akkattu T Biju, Nathalie E Wurz, Frank Glorius

Index: J. Am. Chem. Soc. 132 , 5970-5971, (2010)

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Abstract

The N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated alkynes to provide alpha,beta-unsaturated ketones is reported. In addition, a rare case of an efficient and selective dually NHC-catalyzed cascade reaction involving the hydroacylation of alkynes and a subsequent intermolecular Stetter reaction allows the formation of chromanones containing a 1,4-diketone moiety.