Bulletin of Experimental Biology and Medicine 2001-07-01

Comparative study of modulatory effects of Semax and primary proline-containing peptides on hemostatic reactions.

K A Cherkasova, L A Lyapina, I P Ashmarin

Index: Bull. Exp. Biol. Med. 132(1) , 625-6, (2001)

Full Text: HTML

Abstract

Intranasal administration of Semax, peptide Pro-Gly-Pro, and a mixture of peptides Pro-Gly+Gly-Pro to rats for 5 days enhanced anticoagulant and fibrinolytic potential of the plasma (total fibrinolytic activity and plasmin and plasminogen activator activities) and decreased antiplasmin concentration. Semax and Pro-Gly-Pro decreased the weight of thrombi during experimental thrombosis.