Rationally designed squaryldiamides–a novel class of sugar-nucleotide mimics?

S Niewiadomski, Z Beebeejaun, H Denton…

Index: Niewiadomski, Sven; Beebeejaun, Zeenat; Denton, Helen; Smith, Terry K.; Morris, Richard J.; Wagner, Gerd K. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 15 p. 3488 - 3499

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Citation Number: 12

Abstract

Sugar-nucleotides such as GDP-mannose, GDP-fucose and UDP-glucose are important biomolecules with a central role in carbohydrate and glycoconjugate biosynthesis, metabolism and cell signalling. Analogues and mimics of naturally occurring sugar- nucleotides are sought after as chemical tools and inhibitor candidates for sugar-nucleotide- dependent enzymes including glycosyltransferases. Many sugar-nucleotides bind to their ...