Organic & Biomolecular Chemistry 2011-03-07

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates.

Riccardo Mossetti, Diego Caprioglio, Giampiero Colombano, Gian Cesare Tron, Tracey Pirali

Index: Org. Biomol. Chem. 9(5) , 1627-31, (2011)

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Abstract

α-Isocyanoacetamides, acyl chlorides and dialkylacetylenedicarboxylates undergo a smooth multicomponent reaction to produce dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates in good yield. The scope and mechanism of this new multicomponent transformation are discussed.