Abstract A series of new beta-adrenolytics derived from p-hydroxyacetophenone was synthesized by four methods. The most advantageous was found to be the five-step synthesis via reaction of the intermediate oxirane with amines. The selected compounds reveal a beta-adrenolytic and antiarrhythmic activities.
![1-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3-(propoxymethyl)phenyl]ethanone Structure](https://image.chemsrc.com/caspic/376/104449-98-1.png)
