Journal of heterocyclic chemistry

Preparation and reactions of mono??reissert compounds and analogs at the 3, 4??position of quinazoline

J Kant, FD Popp, BC Uff

Index: Kant, Joydeep; Popp, Frank D.; Uff, Barrie C. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1313 - 1316

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Citation Number: 4

Abstract

Abstract Quinazoline, acid chlorides, and trimethylsilyl cyanide have been converted to mono-Reissert compounds at the 3, 4-position of the quinazoline system. Various reactions of these quinazoline Reissert compounds are reported.

 Related Synthetic Route
4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~%

4-Methylquinazoline Structure

700-46-9

4-Methylquinazoline

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3-benzoyl-3,4-dihydro-4-methyl-4-quinazolinecarbonitrile Structure

98512-47-1

3-benzoyl-3,4-d...

~%

4-Methylquinazoline Structure

700-46-9

4-Methylquinazoline

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ethyl 4-cyano-4H-quinazoline-3-carboxylate Structure

92736-33-9

ethyl 4-cyano-4...

~%

4-Methylquinazoline Structure

700-46-9

4-Methylquinazoline

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α-phenyl-4-quinazolinemethanol Structure

59899-02-4

α-phenyl-4-quin...

~24%

phenyl(quinazolin-4-yl)methanone Structure

55276-35-2

phenyl(quinazol...

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ethyl 4-cyano-4H-quinazoline-3-carboxylate Structure

92736-33-9

ethyl 4-cyano-4...

Benzaldehyde Structure

100-52-7

Benzaldehyde

~15%

phenyl(quinazolin-4-yl)methanone Structure

55276-35-2

phenyl(quinazol...

α-phenyl-4-quinazolinemethanol Structure

59899-02-4

α-phenyl-4-quin...

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4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~%

phenyl(quinazolin-4-yl)methanone Structure

55276-35-2

phenyl(quinazol...

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ethyl 4-cyano-4H-quinazoline-3-carboxylate Structure

92736-33-9

ethyl 4-cyano-4...

o-Anisaldehyde Structure

135-02-4

o-Anisaldehyde

~10%

α-(2-anisyl)-4-quinazolinemethanol Structure

55276-52-3

α-(2-anisyl)-4-...

(2-methoxyphenyl)-quinazolin-4-ylmethanone Structure

55326-11-9

(2-methoxypheny...

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Quinazoline Structure

253-82-7

Quinazoline

~%

(2-methoxyphenyl)-quinazolin-4-ylmethanone Structure

55326-11-9

(2-methoxypheny...

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4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~%

(2-methoxyphenyl)-quinazolin-4-ylmethanone Structure

55326-11-9

(2-methoxypheny...

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Quinazoline Structure

253-82-7

Quinazoline

Trimethylsilyl cyanide Structure

7677-24-9

Trimethylsilyl ...

Ethyl chloroformate Structure

541-41-3

Ethyl chloroformate

~55%

ethyl 4-cyano-4H-quinazoline-3-carboxylate Structure

92736-33-9

ethyl 4-cyano-4...

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4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~%

ethyl 4-cyano-4H-quinazoline-3-carboxylate Structure

92736-33-9

ethyl 4-cyano-4...

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Quinazoline Structure

253-82-7

Quinazoline

Trimethylsilyl cyanide Structure

7677-24-9

Trimethylsilyl ...

~42%

4-cyano-3,4-dihydroquinazoline hydrochloride Structure

76051-73-5

4-cyano-3,4-dih...

quinazoline-4-carbonitrile Structure

36082-71-0

quinazoline-4-c...

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4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~%

quinazoline-4-carbonitrile Structure

36082-71-0

quinazoline-4-c...

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4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~0%

Quinazoline Structure

253-82-7

Quinazoline

4-quinazolin-4-ylquinazoline Structure

963-80-4

4-quinazolin-4-...

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4-cyano-3-(4-chlorobutyryl)-3,4-dihydroquinazoline Structure

104548-10-9

4-cyano-3-(4-ch...

~61%

Quinazoline Structure

253-82-7

Quinazoline

4-quinazolin-4-ylquinazoline Structure

963-80-4

4-quinazolin-4-...

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