Toxicology Letters 2014-06-16

Toxicity of TDCPP and TCEP on PC12 cell: Changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels

Na Ta, Chaonan Li, Yanjun Fang, Huanliang Liu, Bencheng Lin, Hong Jin, Lei Tian, Huashan Zhang, Wei Zhang, Zhuge Xi

Index: Toxicol. Lett. 227(3) , 164-71, (2014)

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Abstract

• The toxicity of TDCPP/TCEP in undifferentiated and differentiated PC12 cells was modelled. • Both cytotoxicity and neurotoxicity were elicited by TDCPP/TCEP. • CAMKII, GAP43, tubulin and NF-H maybe useful biomarkers for the cytotoxicity and neurotoxicity.