Tetrahedron

Straightforward access to cyclic amines by dinitriles reduction

…, L Pehlivan, E Métay, A Favre-Reguillon, D Delbrayelle…

Index: Laval, Stephane; Dayoub, Wissam; Pehlivan, Leyla; Metay, Estelle; Favre-Reguillon, Alain; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc Tetrahedron, 2014 , vol. 70, # 4 p. 975 - 983

Full Text: HTML

Citation Number: 4

Abstract

Abstract 1, 1, 3, 3-Tetramethyldisiloxane (TMDS) and polymethylhydrosiloxane (PMHS), when associated with titanium (IV) isopropoxide, provide two convenient systems for the reduction of nitriles into the corresponding primary amines. Kinetics of the two systems have been studied by 1 H NMR and demonstrated that reduction with PMHS occurs faster than with TMDS. These two titanium-based systems reduce both aromatic and aliphatic nitriles ...