Discovery of 1-Methyl-1 H-imidazole Derivatives as Potent Jak2 Inhibitors

Q Su, S Ioannidis, C Chuaqui, L Almeida…

Index: Journal of Medicinal Chemistry, , vol. 57, # 1 p. 144 - 158

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Citation Number: 22

Abstract

... Journal of Medicinal Chemistry. ... event in all patients with MPNs, comprising essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF).(5) MF is associated with the lowest survival rate among MPNs and represents a significant unmet medical need.(6 ...