Obstetrics and Gynecology Clinics of North America 2012-12-01

Evaluation and treatment of anovulatory and unexplained infertility.

Anthony M Propst, G Wright Bates

Index: Obstet. Gynecol. Clin. North Am. 39(4) , 507-19, (2012)

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Abstract

Anovulatory disorders are a primary cause of female infertility. Polycystic ovarian syndrome is the major cause of anovulation and is generally associated with obesity. Lifestyle changes to encourage weight loss are the initial therapy for overweight and obese patients, followed by clomiphene citrate for ovulation induction. For those patients who fail to ovulate on clomiphene citrate, alternatives, such as letrozole; gonadotropins; and complimentary agents to enhance clomiphene citrate, such as metformin and glucocorticoids, are reviewed. Women with unexplained infertility (no identifiable cause of infertility on a routine evaluation) may benefit from ovulation induction with clomiphene citrate, letrozole, or gonadotropins.Copyright © 2012 Elsevier Inc. All rights reserved.