Indanylidenes. 1. Design and synthesis of (E)-2-(4, 6-difluoro-1-indanylidene) acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and …

DL Musso, FR Cochran, JL Kelley…

Index: Journal of Medicinal Chemistry, , vol. 46, # 3 p. 399 - 408

Full Text: HTML

Citation Number: 52

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The (E)-indanylidenes (see Table 1) were prepared by several methods. The most often used method was method A, as depicted in Scheme 1. The key intermediate in this method is the appropriately substituted indanone. ...