Synthesis and broncholytic activity of 3, 3-disubstituted oxetanes

…, DN Lazareva, ES Kurmaeva, OB Chalova…

Index: Zarudii, F. S.; Lazareva, D. N.; Kurmaeva, E. S.; Chalova, O. B.; Kiladze, T. K.; et al. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 2 p. 108 - 111 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 2 p. 161 - 165

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Abstract

3, 3-Bis (chloromethyl) oxetane is commercially available and is used as a monomer in the manufacture of Pentaplast [4]. The occurrence of several reactive sites in the same molecule (the two chlorine atoms and the oxetane ring) enables the oxetane (I) to be regarded as a convenient intermediate for the preparation of many derivatives. Thus, methods have been developed for the conversion of (I) into 1, 3-dioxanes [5, 6] and alkoxymethyloxetanes [2]. ...