Design and synthesis of 3-(azol-1-yl) phenylpropanes as microbicidal spermicides for prophylactic contraception

L Kumar, A Sarswat, N Lal, A Jain, S Kumar…

Index: Kumar, Lalit; Sarswat, Amit; Lal, Nand; Jain, Ashish; Kumar, Sumit; Kiran Kumar; Maikhuri, Jagdamba P.; Pandey, Atindra K.; Shukla, Praveen K.; Gupta, Gopal; Sharma, Vishnu L. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 176 - 181

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Citation Number: 12

Abstract

We designed a series of 25 3-(azol-1-yl) phenylpropanes which yielded 10 compounds (3, 4, 7, 8, 13, 14, 19, 21, 23, 26) that irreversibly immobilized 100% human sperm at 1%(w/v) concentration in 60s; 12 compounds (8, 9, 15, 16, 19–21, 23–25, 27, 28) that showed potent microbicidal activity at 12.5–50μg/mL against Trichomonas vaginalis; and 17 compounds (3– 11, 13, 15, 19, 21, 23, 26, 28, 30) that exhibited potent anticandida activity with minimum ...