Synthesis of Hindered Anilines: Copper??Catalyzed Electrophilic Amination of Aryl Boronic Esters

RP Rucker, AM Whittaker, H Dang…

Index: Rucker, Richard P.; Whittaker, Aaron M.; Dang, Hester; Lalic, Gojko Angewandte Chemie - International Edition, 2012 , vol. 51, # 16 p. 3953 - 3956

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Citation Number: 67

Abstract

The synthesis of aromatic and heteroaromatic amines has attracted considerable attention in the last two decades as a result of the numerous applications of these compounds in the pharmaceutical industry and medicinal chemistry.[1] The development of several transition- metal-catalyzed couplings of aryl halides with amines [2] has provided a practical method for the preparation of a wide range of anilines.[3] However, some important challenges ...