Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents

…, HG Floss, JM Cassady, WJ Bradner

Index: Crider; Lamey; Floss; Cassady; Bradner Journal of medicinal chemistry, 1980 , vol. 23, # 8 p. 848 - 851

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Citation Number: 26

Abstract

Nitrosourea derivatives 18-22 which utilize either a piperidine or pyridine ring as a carrier group were synthesized and evaluated for anticancer activity. W-(1-Benzyl-4-piperidiny1)-N- (2-chloroethyl)-N-nitrosourea hydrogen maleate (19) exhibited good activity against intracranial L1210 leukemia as well as the mouse ependymoblastoma brain tumor system. Compound 19 exhibited comparable activity in the Lewis lung carcinoma system to N, N'- ...

~50%

~81%

~47%

~80%

Efficient synthesis and identification of novel propane-1, 3...

[Fan, Xing; Zhang, Hu-Shan; Chen, Li; Long, Ya-Qiu European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2827 - 2840]

Potential neuroleptics of the orthopramide series; synthesis...

[Valenta, Vladimir; Holubek, Jiri; Svatek, Emil; Matousova, Oluse; Metysova, Jirina; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, p. 1297 - 1310]

The design and synthesis of purine inhibitors of CDK2. III

[Shum; Peet; Weintraub; Le; Zhao; Barbone; Cashman; Tsay; Dwyer; Loos; Powers; Kropp; Wright; Bitonti; Dumont; Borcherding Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1067 - 1078]