ChemSusChem

Chemo??and Regioselective Homogeneous Rhodium??Catalyzed Hydroamidomethylation of Terminal Alkenes to N??Alkylamides

S Raoufmoghaddam, E Drent, E Bouwman

Index: Raoufmoghaddam, Saeed; Drent, Eite; Bouwman, Elisabeth ChemSusChem, 2013 , vol. 6, # 9 p. 1759 - 1773

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Citation Number: 4

Abstract

Abstract A rhodium/xantphos homogeneous catalyst system has been developed for direct chemo-and regioselective mono-N-alkylation of primary amides with 1-alkenes and syngas through catalytic hydroamidomethylation with 1-pentene and acetamide as model substrates. For appropriate catalyst performance, it appears to be essential that catalytic amounts of a strong acid promoter, such as p-toluenesulfonic acid (HOTs), as well as ...