FEBS Letters 1988-05-23

Diol lipids are activators of protein kinase C.

S E Severin, E K Tovmasyan, V I Shvets, J G Molotkovsky, L D Bergelson

Index: FEBS Lett. 232(2) , 286-8, (1988)

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Abstract

Diol lipids (dioleoyl- and dioctanoylethylene glycol) at relatively low concentrations (approximately 10 microM) were found to activate significantly protein kinase C in the presence of phosphatidylserine or phosphatidylinositol. Since diol lipids are widespread minor lipid constituents of many cells [(1974) Chem. Ind., 597-604], it has been suggested that they may be involved in the maintaining of basal protein kinase C activity in the absence of external stimuli.