Journal of Nutritional Science and Vitaminology 1988-10-01

Effects of alpha-tocopherol-nicotinate administration on the microdynamics of phospholipids of erythrocyte membranes in human subjects.

T Koyama, T Araiso

Index: J. Nutr. Sci. Vitaminol. 34(5) , 449-57, (1988)

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Abstract

The effects of alpha-tocopherol-nicotinate on the microdynamic parameters, membrane viscosity, and wobbling angle of phospholipid molecules of healthy human erythrocyte membranes were studied with a nanosecond time-resolved fluorometer. The incorporation of alpha-tocopherol was achieved by oral administration of alpha-tocopherol-nicotinate for one month with dosage of 400 mg/day. The increase in alpha-tocopherol concentration in erythrocytes was confirmed in two subjects. The membrane viscosity in seven healthy subjects decreased significantly from 1.015 +/- 0.137 to 0.888 +/- 0.133 mPa.s. But no changes in the wobbling angle of phospholipid molecules were observed.