Chemical Communications 2011-02-14

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.

Nicholas T Salzameda, Lisa M Eubanks, Joseph S Zakhari, Kyoji Tsuchikama, Nicholas J DeNunzio, Karen N Allen, Mark S Hixon, Kim D Janda

Index: Chem. Commun. (Camb.) 47(6) , 1713-5, (2011)

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Abstract

Clostridium botulinum produces the most lethal toxins known to man, as such they are high risk terrorist threats, and alarmingly there is no approved therapeutic. We report the first cross-over small molecule inhibitor of these neurotoxins and propose a mechanism by which it may impart its inhibitory activity.