Degradation of the Side Chain of (−)??Sclareol: A Very Short Synthesis of nor??Ambreinolide and Ambrox

…, EJ Alvarez??Manzaneda, R Chahboun…

Index: Barrero; Alvarez-Manzaneda; Chahboun; Arteaga Synthetic Communications, 2004 , vol. 34, # 19 p. 3631 - 3643

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Citation Number: 14

Abstract

The synthesis of nor??Ambreinolide (8) from (??)??sclareol (1) was carried out by treatment with KMnO 4 ??Ac 2 O and further alkaline hydrolysis. 8 was directly transformed into (??)??ambrox (11) by reduction with metal borohydride in the presence of Lewis acids. ... The synthesis of nor??Ambreinolide (8) from (??)??sclareol (1) was carried out by treatment with KMnO 4 ??Ac 2 O and further alkaline hydrolysis. 8 was directly transformed into (??)??ambrox (11) by ...