Bioorganic & Medicinal Chemistry Letters 2013-02-01

Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144.

Nobuhiro Koyama, Yuriko Tokura, Yoko Takahashi, Hiroshi Tomoda

Index: Bioorg. Med. Chem. Lett. 23(3) , 860-3, (2013)

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Abstract

A new actinomycete metabolite designated nosokophic acid was isolated from the culture broth of nosokomycin-producing Streptomyces sp. K04-0144, and the structure was elucidated by various NMR experiments. Nosokophic acid was found to be 3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid, a predicted biosynthetic intermediate of nosokomycin-related moenomycins. The compound showed no activity against MRSA, but potentiated imipenem activity against MRSA by 512-fold.Copyright © 2012 Elsevier Ltd. All rights reserved.