e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Design and preparation of serine–threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures: Part 2.1 Synthesis of a …
AB Maude, AP Mehrotra
Index: Maude, Antony B.; Mehrotra, Amit P.; Gani, David Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 17 p. 2513 - 2526
Nodularins and microcystins are complex natural isopeptidic hepatotoxins that serve as subnanomolar inhibitors of the eukaryotic serine–threonine protein phosphatases, PP1 and PP2A. In Part 1 (AP Mehrotra, KL Webster and D. Gani, J. Chem. Soc., Perkin Trans. 1, 1997, preceding paper) each of the key structural or potentially reactive motifs within each macrocycle type was assessed as a contributor towards phosphatase inhibitory efficacy ...
