Journal of the American Chemical Society 2014-04-23

A convergent synthetic platform for single-nanoparticle combination cancer therapy: ratiometric loading and controlled release of cisplatin, doxorubicin, and camptothecin.

Longyan Liao, Jenny Liu, Erik C Dreaden, Stephen W Morton, Kevin E Shopsowitz, Paula T Hammond, Jeremiah A Johnson

Index: J. Am. Chem. Soc. 136(16) , 5896-9, (2014)

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Abstract

The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.