… α-Oxo gold carbenes using bidentate ligands: implication of tricoordinated gold intermediates and the development of an expedient bimolecular assembly of 2, 4- …

Y Luo, K Ji, Y Li, L Zhang

Index: Luo, Yingdong; Ji, Kegong; Zhang, Liming; Li, Yuxue Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17412 - 17415,4

Full Text: HTML

Citation Number: 87

Abstract

2, 4-Oxazole is an important structural motif in various natural products. An efficient modular synthesis of this structure has been achieved via a [3+ 2] annulation between a terminal alkyne and a carboxamide using a gold-catalyzed oxidation strategy. The postulated reactive intermediate, a terminal α-oxo gold carbene, previously known to be highly electrophilic and hence unlikely to be trapped by stoichiometric external nucleophiles, is ...