Carbamazepine derivatives with P2X4 receptor-blocking activity

…, S Weyer, S Dosa, A El-Tayeb, CE Müller

Index: Tian, Maoqun; Abdelrahman, Aliaa; Weinhausen, Stephanie; Hinz, Sonja; Weyer, Stefanie; Dosa, Stefan; El-Tayeb, Ali; Mueller, Christa E. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 1077 - 1088

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Citation Number: 11

Abstract

Abstract Antagonists for the P2 receptor subtype P2X4, an ATP-activated cation channel receptor, have potential as novel drugs for the treatment of neuropathic pain and other inflammatory diseases. In the present study, a series of 47 carbamazepine derivatives including 32 novel compounds were designed, synthesized, and evaluated as P2X4 receptor antagonists. Their potency to inhibit ATP-induced calcium influx in 1321N1 ...