Catalysis today

Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330

S Stella, A Chadha

Index: Stella, Selvaraj; Chadha, Anju Catalysis Today, 2012 , vol. 198, # 1 p. 345 - 352

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Citation Number: 12

Abstract

Biocatalytic reduction of primary and secondary α-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-α-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88–99%) as compared to the secondary (R)-α-hydroxy amides.

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