Tetrahedron

A straightforward synthesis of N-monosubstituted α-keto amides via aerobic benzylic oxidation of amides

J Shao, X Huang, S Wang, B Liu, B Xu

Index: Shao, Jun; Huang, Xiaomei; Wang, Siyuan; Liu, Bingxin; Xu, Bin Tetrahedron, 2012 , vol. 68, # 2 p. 573 - 579

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Citation Number: 18

Abstract

An efficient sodium bicarbonate promoted aerobic oxidation reaction to prepare N- monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate (TBAHS) was described. This reaction provides a very simple and convenient synthetic route to N-monosubstituted α-keto amides from easily available aryl-or heteroarylacetamides in good to high yields without using toxic reagents and harsh conditions.