Organic Letters 2010-06-04

Synthesis of (+/-)-eusynstyelamide A.

Olga V Barykina, Barry B Snider

Index: Org. Lett. 12(11) , 2664-7, (2010)

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Abstract

The synthesis of (+/-)-eusynstyelamide A has been accomplished in six steps in 13% overall yield from 6-bromoindole, methyl glycidate, and Boc-protected agmatine. If oxygen is carefully excluded from the reaction, the key NaOH-catalyzed aldol dimerization of the alpha-ketoamide proceeded efficiently to give Boc-protected eusynstyelamide A.

Structure	Name/CAS No.	Molecular Formula	Articles
	4-Bromo-2-nitrotoluene CAS:60956-26-5	C₇H₆BrNO₂

Synthetic studies on perophoramidine and the communesins: co...
2006-11-10
[J. Org. Chem. 71(23) , 8891-900, (2006)]

Synthesis of 4-Bromo-2-chlorotoluene. Xue XM, et al.
[Chin. J. Pharm. 37(9) , 588, (2006)]

A Simple, Safe and Efficient Synthesis of Tyrian Purple (6, ...
[Molecules 15(8) , 5561-5580, (2010)]

Tyrian purple: 6, 6'-dibromoindigo and related compounds. Co...
[Molecules 6(9) , 736-769, (2001)]

The bromo-2-nitrobenzoic acids. Erickson JLE, et al.
[J. Am. Chem. Soc. 74(22) , 5621-5623, (1952)]

Synthesis of (+/-)-eusynstyelamide A.

Abstract

Related Compounds