Chemistry & Biodiversity 2011-11-01

Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069.

Xiang-Jing Wang, Ji Zhang, Ji-Dong Wang, Sheng-Xiong Huang, Yi-Hua Chen, Chong-Xi Liu, Wen-Sheng Xiang

Index: Chem. Biodivers. 8(11) , 2117-25, (2011)

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Abstract

Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with literature data. All compounds exhibited noticeable acaricidal and insecticidal activities. Especially compound 2 was found to be the most potent pesticide of the compounds evaluated with the IC(50) values of 10.2, 65.1 and 124.4 μg/ml against adult two-spotted spider mites (Tetranychus urticae Koch), two-spotted spider mite eggs, and Mythimna separata, respectively, which are comparable to those of commercial pesticide milbemycin A(3)/A(4) as positive reference.Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.