Doramectin

Modify Date: 2024-01-02 22:00:25

Doramectin structure	Common Name	Doramectin
	CAS Number	117704-25-3	Molecular Weight	899.114
	Density	1.3±0.1 g/cm3	Boiling Point	967.4±65.0 °C at 760 mmHg
	Molecular Formula	C₅₀H₇₄O₁₄	Melting Point	116 - 119ºC
	MSDS	Chinese USA	Flash Point	274.4±27.8 °C
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of Doramectin

Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins.

Name	doramectin
Synonym	More Synonyms

Description	Doramectin is an antiparasitic agent.IC50 Value:Target: AntiparasiticDoramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
References	[1]. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU. Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion. Exp Appl Acarol. [2]. Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS. Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069. Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295. [3]. Sarre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T. Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium. Vet Parasitol. 2012 Apr 30;185(2-4):346-51. [4]. Lobetti R. .Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8. [5]. Wang JB, Pan HX, Tang GL. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3320-3.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

References

[1]. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU. Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion. Exp Appl Acarol.

[2]. Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS. Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069. Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295.

[3]. Sarre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T. Doramectin resistance in Haemonchus contortus on an alpaca farm in Belgium. Vet Parasitol. 2012 Apr 30;185(2-4):346-51.

[4]. Lobetti R. .Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8.

[5]. Wang JB, Pan HX, Tang GL. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3320-3.

Density	1.3±0.1 g/cm3
Boiling Point	967.4±65.0 °C at 760 mmHg
Melting Point	116 - 119ºC
Molecular Formula	C₅₀H₇₄O₁₄
Molecular Weight	899.114
Flash Point	274.4±27.8 °C
Exact Mass	898.507874
PSA	170.06000
LogP	7.16
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.580
Storage condition	0-6°C
Water Solubility	methanol: soluble

Doramectin MSDS(Chinese)

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T,N,Xi
Risk Phrases	R25
Safety Phrases	33-45-60-61-36/37-26
RIDADR	UN 2811 6.1/PG 3

Anthelmintic resistance in a herd of alpacas (Vicugna pacos).

Can. Vet. J. 53(12) , 1310-3, (2012)

A herd of alpacas was examined because of a history of severe endoparasitism, anemia, hypoproteinemia, and weight loss. Resistance of gastrointestinal nematodes to albendazole, fenbendazole, and doram...

Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin.

J. Pharm. Pharmacol. 62(3) , 393-9, (2010)

Multidrug resistance (MDR) is a serious obstacle encountered in cancer treatment. This study was performed to explore the reversal of MDR by doramectin from the avermectin family and nemadectin belong...

The influence of gastrointestinal parasitism on fecal elimination of doramectin, in lambs.

Ecotoxicol. Environ. Saf. 73(8) , 2017-21, (2010)

A study was done to investigate the effect of parasitism on patterns of doramectin (DRM) fecal elimination in lambs. Fourteen Suffolk Down parasitized lambs (26.9 ± 1.5 kg body weight: bw) were purpos...

Doromectin

extended von Baeyer nomenclature: (10E,14E,16E)-(1R,4S,5’S,6S,6’R,8R,12S,13S,20R,21R,24S)-6’-cyclohexyl-21,24-dihydroxy-5’,11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2’-(5’,6’-dihydro-2’H-pyran)-12-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside

Doramectina

Doramectin

25-cyclohexyl-avermectin B1

DONGGUAI.P.E

bridged fused ring systems nomenclature: (2aE,4E,8E)-(5’S,6S,6’R,7S,11R,13S,15S,17aR,20R,20aR,20bS)-6’-cyclohexyl-5’,6,6’,7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5’,6,8,19-tetramethyl-17-oxospiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2’-[2H]pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside

Dectoma

Dectomax

25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1a

Doramecin

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Doramectin
Price: ￥428.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Moxidectin
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Doramectin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Doramectin

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