Synthesis and properties of DNA containing cyclonucleosides

…, A Horhota, N Greco, CV Christianson…

Index: Yueh, Han; Yu, Hongchuan; Theile, Christopher S.; Pal, Ayan; Horhota, Allen; Greco, Nicholas; Christianson, Carl V.; McLaughlin, Larry W. Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 9 p. 661 - 679

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Citation Number: 4

Abstract

DNA damage is a ubiquitous part of the cellular life cycle. Oxidative stress is particularly problematic for nucleic acids. In many cases, this stress is initiated by a free radical, commonly the hydroxyl radical (·OH). Hydroxyl radicals are generated by both exogenous agents such as carcinogenic molecules and ionization radiation, as well as endogenous sources. [ 1 1. Halliwell , B. and Gutteridge , JMC 2007. Free Radicals in Biology and Medicine, Oxford, New York: Oxford University ...