A general and facile one-pot process of isothiocyanates from amines under aqueous conditions

…, J Shao, W Mo, B Hu, Z Shen, X Hu

Index: Sun, Nan; Li, Bin; Shao, Jianping; Mo, Weimin; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 61 - 70

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Citation Number: 21

Abstract

Abstract A general and facile one-pot protocol for the preparation of a broad range of alkyl and aryl isothiocyanates has been developed from their corresponding primary amines under aqueous conditions. This synthetic process involves an in situ generation of a dithiocarbamate salt from the amine substrate by reacting with CS 2 followed by elimination to form the isothiocyanate product with cyanuric acid as the desulfurylation reagent. The ...

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