Organic Letters 2009-01-15

ortho-Lithiophenyl isocyanide: a versatile precursor for 3H-quinazolin-4-ones and 3H-quinazolin-4-thiones.

Alexander V Lygin, Armin de Meijere

Index: Org. Lett. 11(2) , 389-92, (2009)

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Abstract

ortho-Lithiophenyl isocyanide has been generated from ortho-bromophenyl isocyanide and successfully employed toward the synthesis of 2-substituted phenyl isocyanides as well as 2,3-disubstituted 3H-quinazoline-4-ones and 3H-quinazolin-4-thiones.