A General and Efficient Suzuki–Miyaura Cross??Coupling Protocol Using Weak Base and No Water: The Essential Role of Acetate

B Wang, HX Sun, ZH Sun

Index: Wang, Bing; Sun, Hui-Xia; Sun, Zhi-Hua European Journal of Organic Chemistry, 2009 , # 22 p. 3688 - 3692

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Citation Number: 7

Abstract

Abstract A weak base, CsOAc, promotes Suzuki–Miyaura cross-coupling and related Pd- catalyzed reactions under anhydrous conditions as effectively as stronger bases. Aryl triflates exhibit unusual reaction rates, which are comparable to that of bromoarenes. A neglected six-membered transition-state model was proposed to give alternative insight into the key process of transmetalation.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 ...