Tetrahedron letters

One-pot approach for the regioselective synthesis of β-keto sulfones based on acid-catalyzed reaction of sulfonyl chlorides with arylacetylenes and water

C Lai, C Xi, Y Jiang, R Hua

Index: Lai, Chunbo; Xi, Chanjuan; Jiang, Yanfeng; Hua, Ruimao Tetrahedron Letters, 2005 , vol. 46, # 3 p. 513 - 515

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Citation Number: 21

Abstract

Sulfone compounds have drawn increasing attention in organic synthesis. Among their derivatives, β-keto sulfones display a broad range of synthetic versatilities 1 and 2 and some exhibit fungicidal activity. 3 Considering the importance of β-keto sulfones, the development of synthetic methodology for β-keto sulfones is of great interest. The existing approach includes: (i) acylation of α-sulfonyl carbanions; 4 (ii) alkylation of metallic arene sulfinates; ...