Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles

LJ Powers, SW Fogt, ZS Ariyan, DJ Rippin…

Index: Powers, Larry J.; Fogt, S. W.; Ariyan, Z. S.; Rippin, D. J.; Heilman, R. D.; Matthews, Richard J. Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 604 - 609

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Citation Number: 13

Abstract

The effect of structural change on the biological activity of a series of imidazothiazoles and thiazolobenzimidazoles is described. It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity. Other structural changes, such as the incorporation of a gem- dimethyl substituent in the 6 position, increase acute toxicity and eliminate ...