Organic Letters 2004-05-27

Pd-catalyzed carbonylative lactamization: a novel synthetic approach to FR900482.

Barry M Trost, Michael K Ameriks

Index: Org. Lett. 6 , 1745, (2004)

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Abstract

An asymmetric synthesis of the benzazocine core of FR900482 has been achieved in 15 steps from 3,5-dinitro-p-toluic acid. Key features of the synthesis include an enantioselective N-methylephedrine-mediated zinc acetylide addition to a highly enolizable arylacetaldehyde and a novel Pd-catalyzed carbonylative lactamization to form an eight-membered ring. [reaction--see text]