Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1, 7-naphthyridines: a novel class of potent and selective phosphodiesterase type …

R Hersperger, K Bray-French, L Mazzoni…

Index: Journal of Medicinal Chemistry, , vol. 43, # 4 p. 675 - 682

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Citation Number: 48

Abstract

... Journal of Medicinal Chemistry. ... 1,2 Originally fuelled mainly by preclinical findings, this approach has received substantial support from recent clinical studies, and the search for novel PDE4 inhibitors is currently one of the most active fields in the pharmaceutical industry. ...

Elucidation of a structural basis for the inhibitor-driven, ...

[Day, Jonathan P.; Lindsay, Barbara; Riddell, Tracy; Jiang, Zhong; Allcock, Robert W.; Abraham, Achamma; Sookup, Sebastian; Christian, Frank; Bogum, Jana; Martin, Elisabeth K.; Rae, Robert L.; Anthony, Diana; Rosair, Georgina M.; Houslay, Daniel M.; Huston, Elaine; Baillie, George S.; Klussmann, Enno; Houslay, Miles D.; Adams, David R. Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3331 - 3347]

A scalable synthesis of a 1, 7-naphthyridine derivative, a P...

[Organic Process Research and Development, , vol. 14, # 4 p. 883 - 889]

Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamy...

[Journal of Medicinal Chemistry, , vol. 54, # 13 p. 4735 - 4751]