Oligonucleotide synthesis. Part 21. Synthesis of ribooligonucleotides using the 4-methoxybenzyl group as a new protecting group for the 2'-hydroxyl group

H Takaku, K Kamaike, H Tsuchiya

Index: Takaku, Hiroshi; Kamaike, Kazuo; Tsuchiya, Hiromichi Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 51 - 56

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Citation Number: 47

Abstract

The 4-methoxybenzyl group was introduced to protect the 2'-hydroxyl group of uridine, cytidine, and N?-benzoylguanosine by treatment of 2', 3 '-0-(dibutylstannylene) uridine or NaH-treated nucleosides with 4-methoxybenzyl bromide. The 2'-0-(4methoxybenzyl) nucleosides can be used as useful starting materials for the synthesis of 3', 5 '-linked ribooligonucleotides. The 4-methoxybenzyl group wm removed rapidly from the ...