Interphenylene 7-oxabicyclo [2.2. 1] heptane thromboxane A2 (TxA2) antagonists. Semicarbazone. omega.-chains

…, DN Harris, A Hedberg, ML Webb, SE Hall

Index: Misra; Brown; Han; Harris; Hedberg; Webb; Hall Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2882 - 2891

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Citation Number: 20

Abstract

A series of chiral interphenylene 7-oxabicyclo [2.2. l] heptane semicarbazones 19-26 were prepared and evaluated for their in vitro thromboxane (TxA,) antagonistic activity and in vivo duration of action. The potency of 19-26 was found to highly dependent on the substitution pattern of the interphenylene ring and decreased in the order ortho> meta>> para. SQ 35,091 (25),[lS-(la, 2a, 3a, 4a)]-2-[[3-[[[(phenylamino) carbonyl] hydrazono] methyl]-7- ...