Tetrahedron

Microwave-assisted methylation of phenols with tetramethylammonium chloride in the presence of K 2 CO 3 or Cs 2 CO 3

N Maraš, S Polanc, M Kočevar

Index: Maras, Nenad; Polanc, Slovenko; Kocevar, Marijan Tetrahedron, 2008 , vol. 64, # 51 p. 11618 - 11624

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Citation Number: 40

Abstract

We have evaluated the potential of using tetramethylammonium chloride (Me4NCl) as an alternative methylating agent for phenols under microwave-assisted conditions. Its chemical behavior was tested in a reaction with 2-naphthol in the presence of various bases and solvents. The method was then applied in 1, 2-dimethoxyethane or toluene under heterogeneous conditions for the O-methylation of a series of phenolic compounds. We ...