Voprosy Meditsinskoi Khimi 2002-01-01

[Effect of nicotinamide adenine dinucleotide on the serotoninergic mediator system in the rat brain during 3-acetylpyridine administration].

T M Kuchmerovskaia, G V Chichkovskaia, L V Pakirbaeva, A A Khalmuradov

Index: Vopr. Med. Khim. 48(3) , 264-70, (2002)

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Abstract

The effect of administration of 3-acetylpyridine (antivitamin B3), on rat brain serotoninergic and NAD receptor systems was investigated. The injection of 3-acetylpyridine to rats caused a decrease of NAD and serotonin content in the brain and changes in [U-14C]NAD binding to synaptic membranes, serotonin uptake by nerve endings, as well as sensitivity of this process to NAD (10-5 M). Pretreatment of animals with nicotinamide restored modulating effect of NAD.