Labeling approaches for the GE11 peptide, an epidermal growth factor receptor biomarker

…, A Hagooly, S Elmachily, E Mishani

Index: Dissoki, Samar; Hagooly, Aviv; Elmachily, Smadar; Mishani, Eyal Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 11 p. 693 - 701

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Citation Number: 7

Abstract

The epidermal growth factor receptor (EGFR) is involved in the proliferation and differentiation of normal and malignant cells and is a major therapeutic target for a variety of human cancers. The peptide GE11 was reported to bind efficiently to the EGFR. Labeling GE11 with radionuclides may aid in the quantification of EGFR expression in tumors via noninvasive imaging. To this end, a GGGK linker was attached to the peptide (GE11′), ...