Synthesis and antifungal activity evaluation of 3-hetaryl-2, 5-dihydrofuran-2-ones. An unusual fragmentation of the oxazole ring via 2, 3-selenoxide shift

…, V Balšánek, M Pour, V Buchta

Index: Kunes, Jiri; Balsanek, Vojtech; Pour, Milan; Buchta, Vladimir Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 12 p. 1809 - 1830

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Citation Number: 12

Abstract

Abstract In continuing the studies on the synthesis and evaluation of antifungal activity of the analogues of (-) incrustoporine, the replacement of the phenyl moiety at C3 of the furanone ring with a hetaryl substituent was considered. Thus, a series of 5-alkyl-3-hetaryl-2, 5- dihydrofuran-2-ones with the thienyl, furyl and thiazolyl moieties attached to C3 was synthesized, and the compounds subjected to antifungal activity screening. In the ...