Steroids 2014-09-01

Epigenetic modifier-induced biosynthesis of novel acetylenic sterols from Cladosporium colocasiae.

Dong-Ze Liu, Bo-Wen Liang, Xiao-Fei Li, Zhi-Yuan Yu

Index: Steroids 87 , 35-8, (2014)

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Abstract

The addition of an HDAC inhibitor, suberoylanilide hydroxamic acid (SBHA), to the culture medium of Cladosporium colocasiae, dramatically altered its metabolic profiles. Analysis of the culture broth extract led to the isolation of two new acetylenic sterols (1-2). The isolated compounds were further evaluated for their cytotoxic and antibacterial activities. Compound 1 showed activity against Bacillus subtilis, affording a zone of inhibition of 12mm at 100μg/disk. However, none of them showed noticeable growth inhibitory effects. Copyright © 2014. Published by Elsevier Inc.