A Convenient Method for the Synthesis of 3, 5, 6-Trisubstituted-2-chloropyridines with bis-(Trichloromethyl) Carbonate

ZH Li, B Hong, WK Su

Index: Li; Hong; Su Organic Preparations and Procedures International, 2009 , vol. 41, # 6 p. 533 - 538

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Citation Number: 2

Abstract

The pyridine ring system is found in a large number of naturally occurring alkaloids and synthetic products of biological interest. 1–4 Therefore, continuing studies forward the synthesis of pyridines are important in the field of drug design. As shown in Figure 1, 3, 5, 6- trisubstituted-2-chloropyridines have been extensively used as versatile building blocks for the synthesis of many heterocyclic systems with potential biological activity. 5, 6 The ...