Biomedical Chromatography 2005-09-01

High-performance liquid chromatographic mass spectrometric identification of the photoproducts of cymoxanil.

Patrizia Morrica, Paola Fidente, Serenella Seccia

Index: Biomed. Chromatogr. 19(7) , 506-12, (2005)

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Abstract

The photochemical degradation of the fungicide cymoxanil {2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino) acetamide} was studied in aqueous buffer solution (pH 5.9+/- 0.1) under UV light and in laboratory conditions. The degradation followed a pseudo- first-order kinetic with significant correlation coefficient. The main photoproducts were separated and tentatively identified by HPLC/UV and HPLC/MS data, as 3-ethyl-4-(methoxyamino)-2,5-dioxo-4-imidazolidinecarbonitrile, 1-ethyl-5-(methoxyimino)-2,4-imidazolidin-2,4-dione, ethylimidazolidinetrione and {[(ethylamino)carbonyl]-amino}oxoacetic acid. A photolysis pathway of cymoxanil is proposed.Copyright (c) 2005 John Wiley & Sons, Ltd.