Tetrahedron: Asymmetry

An efficient access to the enantiomers of α-methyl-4-carboxyphenylglycine via a hydantoin route using a practical variant of preferential crysallization AS3PC (Auto …

E Ndzié, P Cardinael, AR Schoofs, G Coquerel

Index: Ndzie; Cardinael; Schoofs; Coquerel Tetrahedron Asymmetry, 1997 , vol. 8, # 17 p. 2913 - 2920

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Citation Number: 40

Abstract

The enantiomers are obtained in preparative amounts without a resolving agent via the following sequence: hydantoin synthesis, resolution by entrainment, and ring cleavage by means of hydrolysis in basic conditions. The new variant of preferential crystallization (AS3PC), implemented without using seeds, shows good reproducibility and yield.